Begun in 1995 by former printer and homebrewer Johan Brandt, it was originally titled "De Regenboog", the same name as his earlier printing business. Brandt is also a bee-keeper, which accounts for the prominent use of honey in some of the brewery's offerings, including its first commercial beer, which was named 't Smisje or "the little blacksmith" to reflect the hand-crafted nature of the product as well as a local landmark blacksmith's house near the brewery's original location.
From 1995-2008, the brewery was located in the West Flanders municipality of Assebroek, a suburb of Bruges. In 2008 it relocated to the village of Mater in Oudenaarde, East Flanders and changed its name to simply "Smisje". Smisje is known for beers in both traditional Belgian styles and others, but particularly for brewing with distinctive ingredients and flavorings,[3] often fruits or herbs. This experimental brewery exports roughly half of its annual product outside of Belgium to countries such as the United States, The Netherlands, Italy, Spain and Denmark. Despite its minuscule size, for many years Smisje has kept six beers in regular production in addition to a large variety of seasonal and occasional brews. Many of their beers have featured label art by Brooklyn cartoonist and craft beer enthusiast Bill Coleman.
In 2010, the brewery announced that it would be discontinuing all of its historic products in order to focus on a new blond, hoppy ale to be called "Smiske". Only the annual "Smisje Christmas" would be preserved. Following the example of Duvel Moortgat, who offered to brew again their limited-edition "Duvel Triple Hop" if 10,000 people would sign a petition for it, Brandt announced that if 20,000 people would join a Facebook group supporting it, he would offer to brew one additional historic recipe per year
